[54] LSU 17-31 Mississippi [24] 2021-10-23 19:30
Stadium: Vaught-Hemingway Stadium Round: 1
Home Manager: Lane Kiffin Away Manager: Ed Orgeron
Head to Head
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | W | 48-53 |
| NCAAF | 2019/11/17 00:00 | LSU v Mississippi | W | 58-37 |
| NCAAF | 2018/09/30 01:15 | Mississippi v LSU | W | 16-45 |
| NCAAF | 2017/10/21 23:15 | LSU v Mississippi | W | 40-24 |
| NCAAF | 2016/10/23 01:00 | Mississippi v LSU | W | 21-38 |
| NCAAF | 2015/11/21 20:30 | Mississippi v LSU | L | 38-17 |
| NCAAF | 2014/10/25 23:15 | LSU v Mississippi | W | 10-7 |
| NCAAF | 2012/11/17 12:00 | LSU v Mississippi | W | 41-35 |
Home History
| NCAAF | 2021/10/16 16:00 | Florida v LSU | W | 42-49 |
| NCAAF | 2021/10/09 23:30 | LSU v Kentucky | L | 21-42 |
| NCAAF | 2021/10/03 01:00 | Auburn v LSU | L | 24-19 |
| NCAAF | 2021/09/25 16:00 | LSU v Mississippi State | W | 28-25 |
| NCAAF | 2021/09/18 23:30 | Central Michigan v LSU | W | 21-49 |
| NCAAF | 2021/09/12 00:00 | McNeese State v LSU | W | 7-34 |
| NCAAF | 2021/09/05 00:30 | LSU v UCLA | L | 27-38 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | W | 48-53 |
Away History
| NCAAF | 2021/10/16 23:30 | Mississippi v Tennessee | W | 31-26 |
| NCAAF | 2021/10/09 16:00 | Arkansas v Mississippi | W | 51-52 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | L | 21-42 |
| NCAAF | 2021/09/19 00:00 | Tulane v Mississippi | W | 21-61 |
| NCAAF | 2021/09/11 23:30 | Austin Peay v Mississippi | W | 17-54 |
| NCAAF | 2021/09/07 00:00 | Louisville v Mississippi | W | 24-43 |
| NCAAF | 2021/01/02 17:30 | Mississippi v Indiana | W | 26-20 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | L | 48-53 |
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