Stadium: Bailey Memorial Stadium Round: 1
Home Manager: Steve Englehart Away Manager: Glenn Caruso
| NCAAF | 2022/10/15 18:00 | Drake Bulldogs v St.Thomas MIN | W | 14-26 |
| NCAAF | 2022/10/08 18:00 | Davidson Wildcats v St.Thomas MIN | W | 16-27 |
| NCAAF | 2022/10/01 16:00 | St.Thomas MIN v Marist | W | 38-24 |
| NCAAF | 2022/09/24 18:00 | St.Thomas MIN v Lincoln Oaklanders | W | 43-6 |
| NCAAF | 2022/09/10 18:00 | St.Thomas MIN v Michigan Technological University Huskies | W | 32-6 |
| NCAAF | 2022/09/02 00:00 | St.Thomas MIN v Southern Utah | L | 13-44 |
| NCAAF | 2021/11/20 19:00 | Presbyterian v St.Thomas MIN | W | 15-54 |
| NCAAF | 2021/11/13 18:00 | St.Thomas MIN v Drake Bulldogs | W | 21-14 |
| NCAAF | 2022/10/15 21:00 | Presbyterian v San Diego | L | 3-28 |
| NCAAF | 2022/10/08 16:00 | Valparaiso v Presbyterian | L | 41-21 |
| NCAAF | 2022/10/01 17:00 | Presbyterian v Morehead State | L | 10-14 |
| NCAAF | 2022/09/24 23:00 | Davidson Wildcats v Presbyterian | L | 56-24 |
| NCAAF | 2022/09/17 19:30 | Presbyterian v Western Carolina | L | 21-77 |
| NCAAF | 2022/09/10 17:00 | Presbyterian v Lynchburg Dragons | W | 21-13 |
| NCAAF | 2022/09/03 23:00 | Presbyterian v Austin Peay | L | 0-63 |
| NCAAF | 2021/11/20 19:00 | Presbyterian v St.Thomas MIN | L | 15-54 |