Stadium: Jack Spinks Stadium Round: 1
Home Manager: Fred McNair Away Manager: Colby Carthel
| NCAAF | 2021/11/27 20:00 | Stephen F. Austin v Incarnate Word | L | 28-35 |
| NCAAF | 2021/11/20 22:00 | Stephen F. Austin v Lamar | W | 42-6 |
| NCAAF | 2021/11/13 22:00 | Stephen F. Austin v Central Arkansas | W | 27-14 |
| NCAAF | 2021/11/06 21:00 | Eastern Kentucky v Stephen F. Austin | W | 17-31 |
| NCAAF | 2021/10/30 21:00 | Abilene Christian v Stephen F. Austin | W | 27-41 |
| NCAAF | 2021/10/24 01:00 | Stephen F. Austin v Utah Tech | W | 37-20 |
| NCAAF | 2021/10/09 20:00 | Stephen F. Austin v Jacksonville State | L | 24-28 |
| NCAAF | 2021/10/02 21:00 | Sam Houston State v Stephen F. Austin | L | 21-20 |
| NCAAF | 2021/11/20 19:00 | Alcorn State v Jackson State | L | 10-24 |
| NCAAF | 2021/11/13 20:00 | Prairie View v Alcorn State | W | 29-31 |
| NCAAF | 2021/11/06 16:00 | Alcorn State v Bethune Cookman | L | 31-35 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | L | 35-38 |
| NCAAF | 2021/10/24 00:00 | Alcorn State v Texas Southern Tigers | W | 44-27 |
| NCAAF | 2021/10/16 20:00 | Alcorn State v Mississippi Valley State | W | 24-12 |
| NCAAF | 2021/10/09 19:00 | Grambling State v Alcorn State | W | 20-24 |
| NCAAF | 2021/09/23 23:30 | Alcorn State v Arkansas Pine Bluff | W | 39-38 |