Stadium: Panther Stadium at Blackshear Field Round: 1
Home Manager: Bubba McDowell Away Manager: G.J. Kinne
| NCAAF | 2021/09/12 00:00 | Prairie View v Incarnate Word | W | 9-40 |
| NCAAF | 2017/11/17 00:00 | Incarnate Word v Prairie View | L | 28-42 |
| NCAAF | 2022/09/10 21:30 | Incarnate Word v Nevada | W | 55-41 |
| NCAAF | 2022/09/03 23:00 | SO Illinois v Incarnate Word | W | 29-64 |
| NCAAF | 2021/12/04 20:00 | Incarnate Word v Sam Houston State | L | 42-49 |
| NCAAF | 2021/11/27 20:00 | Stephen F. Austin v Incarnate Word | W | 28-35 |
| NCAAF | 2021/11/20 20:00 | Incarnate Word v Houston Christian | W | 55-14 |
| NCAAF | 2021/11/13 21:00 | Incarnate Word v Nicholls State | W | 27-23 |
| NCAAF | 2021/11/06 19:00 | SE Louisiana v Incarnate Word | W | 52-55 |
| NCAAF | 2021/10/30 20:00 | Houston Christian v Incarnate Word | W | 21-49 |
| NCAAF | 2022/09/11 00:00 | Prairie View v Abilene Christian | L | 13-21 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | W | 23-40 |
| NCAAF | 2021/12/04 21:00 | Prairie View v Jackson State | L | 10-27 |
| NCAAF | 2021/11/27 20:00 | Mississippi Valley State v Prairie View | L | 24-19 |
| NCAAF | 2021/11/20 17:00 | Prairie View v Texas A&M | L | 3-52 |
| NCAAF | 2021/11/13 20:00 | Prairie View v Alcorn State | L | 29-31 |
| NCAAF | 2021/11/06 19:00 | Alabama State v Prairie View | W | 20-24 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | W | 48-21 |