Stadium: Burgess-Snow Field at JSU Stadium Round: 1
Home Manager: Rich Rodriguez Away Manager: Frank Scelfo
| NCAAF | 2022/10/08 21:00 | Texas A&M-Commerce v SE Louisiana | L | 31-28 |
| NCAAF | 2022/10/01 23:00 | Murray State v SE Louisiana | W | 14-48 |
| NCAAF | 2022/09/24 23:00 | Incarnate Word v SE Louisiana | W | 35-41 |
| NCAAF | 2022/09/17 23:00 | Central Connecticut v SE Louisiana | W | 6-70 |
| NCAAF | 2022/09/10 22:00 | SE Louisiana v Florida Atlantic | L | 9-42 |
| NCAAF | 2022/09/03 23:00 | SE Louisiana v Lafayette | L | 7-24 |
| NCAAF | 2021/12/04 19:00 | SE Louisiana v James Madison | L | 20-59 |
| NCAAF | 2021/11/28 00:00 | Florida A&M v SE Louisiana | W | 14-38 |
| NCAAF | 2022/10/15 23:00 | Jacksonville State v North Alabama | W | 47-31 |
| NCAAF | 2022/10/01 18:00 | Kennesaw State v Jacksonville State | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | W | 52-21 |
| NCAAF | 2022/09/17 23:00 | Jacksonville State v Tulsa | L | 17-54 |
| NCAAF | 2022/09/10 23:00 | Jacksonville State v Murray State | W | 34-3 |
| NCAAF | 2022/09/03 18:00 | Davidson Wildcats v Jacksonville State | W | 17-35 |
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | L | 31-39 |
| NCAAF | 2021/11/13 22:00 | Jacksonville State v Lamar | W | 38-7 |