Stadium: Roy Kidd Stadium Round: 1
Home Manager: Walt Wells Away Manager: K.C. Keeler
| NCAAF | 2022/10/01 19:30 | Stephen F. Austin v Sam Houston State | W | 16-17 |
| NCAAF | 2022/09/17 23:00 | Texas A&M-Commerce v Sam Houston State | W | 17-27 |
| NCAAF | 2022/09/10 23:00 | Northern Arizona v Sam Houston State | L | 10-3 |
| NCAAF | 2022/09/03 16:00 | Sam Houston State v Texas A&M | L | 0-31 |
| NCAAF | 2021/12/12 01:30 | Montana State v Sam Houston State | L | 42-19 |
| NCAAF | 2021/12/04 20:00 | Incarnate Word v Sam Houston State | W | 42-49 |
| NCAAF | 2021/11/20 19:00 | Sam Houston State v Abilene Christian | W | 35-9 |
| NCAAF | 2021/11/13 18:00 | Eastern Kentucky v Sam Houston State | W | 28-42 |
| NCAAF | 2022/10/01 22:00 | Southern Utah v Eastern Kentucky | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Eastern Kentucky v Austin Peay | L | 20-31 |
| NCAAF | 2022/09/17 22:00 | Charleston Southern v Eastern Kentucky | W | 17-40 |
| NCAAF | 2022/09/10 20:00 | Eastern Kentucky v Bowling Green | W | 59-57 |
| NCAAF | 2022/09/02 23:00 | Eastern Kentucky v Eastern Michigan | L | 34-42 |
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | W | 31-39 |
| NCAAF | 2021/11/13 18:00 | Eastern Kentucky v Sam Houston State | L | 28-42 |
| NCAAF | 2021/11/06 21:00 | Eastern Kentucky v Stephen F. Austin | L | 17-31 |