Stadium: Nottingham Field Round: 1
Home Manager: Ed McCaffrey Away Manager: Vic Shealy
| NCAAF | 2021/11/20 20:00 | Incarnate Word v Houston Christian | L | 55-14 |
| NCAAF | 2021/11/13 20:00 | McNeese State v Houston Christian | L | 44-3 |
| NCAAF | 2021/11/06 20:00 | Houston Christian v Northwestern State | L | 24-28 |
| NCAAF | 2021/10/30 20:00 | Houston Christian v Incarnate Word | L | 21-49 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | L | 44-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | L | 24-61 |
| NCAAF | 2021/10/09 23:00 | Northwestern State v Houston Christian | L | 21-17 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | L | 17-48 |
| NCAAF | 2021/11/20 20:00 | Northern Colorado v Weber State | L | 17-48 |
| NCAAF | 2021/11/06 18:00 | Montana v Northern Colorado | L | 35-0 |
| NCAAF | 2021/10/30 19:00 | CS Sacramento v Northern Colorado | L | 27-24 |
| NCAAF | 2021/10/24 00:00 | Northern Colorado v Southern Utah | W | 17-9 |
| NCAAF | 2021/10/17 00:00 | Northern Colorado v UC Davis | L | 3-32 |
| NCAAF | 2021/10/09 19:00 | East Washington v Northern Colorado | L | 63-17 |
| NCAAF | 2021/10/02 19:00 | Northern Colorado v Montana State | L | 7-40 |
| NCAAF | 2021/09/25 19:00 | Northern Arizona v Northern Colorado | W | 10-17 |