Stadium: Villanova Stadium Round: 1
Home Manager: Mark Ferrante Away Manager: Mike London
| NCAAF | 2019/10/05 19:30 | Villanova v William & Mary | L | 35-28 |
| NCAAF FCS | 2018/11/10 18:00 | William & Mary v Villanova | W | 24-17 |
| NCAAF | 2021/10/23 19:30 | Towson v William & Mary | W | 14-40 |
| NCAAF | 2021/10/16 16:00 | William & Mary v Maine | L | 16-27 |
| NCAAF | 2021/10/09 19:30 | Albany v William & Mary | W | 24-31 |
| NCAAF | 2021/09/25 18:00 | William & Mary v Elon | W | 34-31 |
| NCAAF | 2021/09/18 17:00 | William & Mary v Colgate | W | 27-7 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | W | 3-24 |
| NCAAF | 2021/09/04 23:30 | William & Mary v Virginia | L | 0-43 |
| NCAAF | 2021/03/27 17:00 | James Madison v William & Mary | L | 38-10 |
| NCAAF | 2021/10/23 19:30 | Rhode Island v Villanova | W | 0-44 |
| NCAAF | 2021/10/16 19:30 | Villanova v Albany | W | 17-10 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | W | 28-27 |
| NCAAF | 2021/09/25 16:00 | Villanova v Penn State | L | 17-38 |
| NCAAF | 2021/09/18 19:30 | Richmond v Villanova | W | 27-34 |
| NCAAF | 2021/09/11 22:00 | Bucknell v Villanova | W | 3-55 |
| NCAAF | 2021/09/04 16:00 | Villanova v Lehigh | W | 47-3 |
| NCAAF | 2021/04/17 17:00 | Delaware v Villanova | L | 27-20 |