Stadium: Duvall-Rosier Field Round: 1
| NCAAF | 2021/11/06 17:00 | Glenville State Pioneers v Fairmont State | W | 14-24 |
| NCAAF | 2021/10/30 16:00 | Notre Dame Falcons v Fairmont State | L | 45-0 |
| NCAAF | 2021/10/23 17:00 | Fairmont State v Frostburg State | L | 14-49 |
| NCAAF | 2021/10/16 17:00 | West Liberty Hilltoppers v Fairmont State | L | 52-31 |
| NCAAF | 2021/10/09 18:00 | Fairmont State v Alderson Broaddus Battlers | W | 44-10 |
| NCAAF | 2021/10/02 18:00 | Fairmont State v Concord University Mountain Lions | W | 31-27 |
| NCAAF | 2021/09/25 17:00 | Unc Pembroke Braves v Fairmont State | W | 27-30 |
| NCAAF | 2021/09/18 17:00 | Fairmont State v West Virginia State Yellow Jackets | L | 23-30 |
| NCAAF | 2021/11/06 16:00 | University of Charleston Golden Eagles v Wheeling Jesuit | L | 38-20 |
| NCAAF | 2021/10/30 16:00 | Wheeling Jesuit v Concord University Mountain Lions | W | 15-14 |
| NCAAF | 2021/10/23 17:00 | Wheeling Jesuit v West Liberty Hilltoppers | W | 26-20 |
| NCAAF | 2021/10/16 18:00 | Frostburg State v Wheeling Jesuit | L | 41-17 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling Jesuit | L | 34-28 |
| NCAAF | 2021/10/02 18:00 | Wheeling Jesuit v W. Virginia Bobcats | W | 38-0 |
| NCAAF | 2021/09/25 16:00 | Glenville State Pioneers v Wheeling Jesuit | W | 10-27 |
| NCAAF | 2021/09/18 17:00 | Wheeling Jesuit v Alderson Broaddus Battlers | W | 28-6 |