Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: Randy Sanders Away Manager: Drew Cronic
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | W | 13-21 |
| NCAAF | 2019/11/16 18:00 | Mercer v East Tennessee State | L | 33-38 |
| NCAAF FCS | 2018/11/03 19:00 | East Tennessee State v Mercer | L | 21-18 |
| NCAAF | 2017/09/23 19:30 | East Tennessee State v Mercer | L | 26-23 |
| NCAAF | 2021/11/13 20:00 | Tennessee Chattanooga v Mercer | W | 6-10 |
| NCAAF | 2021/10/30 18:00 | Mercer v The Citadel | W | 34-7 |
| NCAAF | 2021/10/23 22:00 | Wofford v Mercer | W | 14-45 |
| NCAAF | 2021/10/16 20:00 | VMI v Mercer | L | 45-7 |
| NCAAF | 2021/10/09 19:30 | Mercer v Western Carolina | W | 34-24 |
| NCAAF | 2021/10/02 22:00 | Samford v Mercer | W | 42-45 |
| NCAAF | 2021/09/25 18:00 | Mercer v Furman | W | 24-3 |
| NCAAF | 2021/09/11 20:00 | Mercer v Alabama | L | 14-48 |
| NCAAF | 2021/11/13 19:00 | East Tennessee State v Western Carolina | W | 56-35 |
| NCAAF | 2021/11/06 17:00 | VMI v East Tennessee State | W | 20-27 |
| NCAAF | 2021/10/23 18:00 | East Tennessee State v Furman | W | 17-13 |
| NCAAF | 2021/10/16 17:30 | East Tennessee State v Tennessee Chattanooga | L | 16-21 |
| NCAAF | 2021/10/09 20:30 | The Citadel v East Tennessee State | W | 21-48 |
| NCAAF | 2021/10/02 19:30 | Wofford v East Tennessee State | W | 21-27 |
| NCAAF | 2021/09/25 19:00 | East Tennessee State v Samford | W | 55-48 |
| NCAAF | 2021/09/18 23:30 | Delaware State v East Tennessee State | W | 6-38 |