Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: Brock Spack
| NCAAF | 2021/02/27 18:00 | South Dakota v Illinois State | L | 27-20 |
| NCAAF | 2017/10/21 19:00 | Illinois State v South Dakota | W | 37-21 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | L | 20-0 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | L | 41-20 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | L | 17-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | L | 0-28 |
| NCAAF | 2021/09/04 23:30 | Butler v Illinois State | W | 7-49 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2021/03/13 20:30 | Illinois State v North Dakota State | L | 13-21 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | W | 34-21 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | W | 13-20 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | W | 10-38 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | L | 23-31 |
| NCAAF | 2021/09/19 00:00 | South Dakota v Cal Poly | W | 48-14 |
| NCAAF | 2021/09/11 18:00 | Northern Arizona v South Dakota | W | 7-34 |
| NCAAF | 2021/09/04 00:00 | South Dakota v Kansas | L | 14-17 |
| NCAAF | 2021/03/20 16:00 | South Dakota v Youngstown State | L | 10-28 |