Stadium: Armstrong Stadium Round: 1
Home Manager: Robert Prunty Away Manager: Tre Lamb
| NCAAF | 2021/10/30 17:00 | Gardner Webb v Kennesaw State | L | 30-34 |
| NCAAF | 2021/10/23 17:30 | Robert Morris v Gardner Webb | W | 17-28 |
| NCAAF | 2021/10/09 22:00 | Campbell v Gardner Webb | L | 42-28 |
| NCAAF | 2021/10/02 17:00 | Gardner Webb v Monmouth | L | 17-54 |
| NCAAF | 2021/09/25 22:00 | Western Carolina v Gardner Webb | W | 34-52 |
| NCAAF | 2021/09/18 22:00 | Gardner Webb v Lincoln University Lions | W | 56-0 |
| NCAAF | 2021/09/11 22:00 | Gardner Webb v Charlotte | L | 10-38 |
| NCAAF | 2021/09/04 22:00 | Gardner Webb v Georgia Southern | L | 25-30 |
| NCAAF | 2021/10/30 16:00 | Hampton v Robert Morris | L | 35-38 |
| NCAAF | 2021/10/23 18:00 | North Carolina A&T v Hampton | W | 9-30 |
| NCAAF | 2021/10/16 22:00 | Hampton v Charleston Southern | L | 5-35 |
| NCAAF | 2021/10/09 18:00 | Kennesaw State v Hampton | L | 34-15 |
| NCAAF | 2021/10/02 18:00 | Norfolk State v Hampton | L | 47-44 |
| NCAAF | 2021/09/18 16:00 | Hampton v Howard | W | 48-32 |
| NCAAF | 2021/09/11 23:00 | Hampton v Old Dominion | L | 7-47 |
| NCAAF | 2021/09/04 22:00 | Hampton v Virginia Union Panthers | W | 42-28 |