South Carolina State 3-49 Clemson 2021-09-11 21:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Oliver Pough
Head to Head
| NCAAF | 2016/09/17 16:00 | Clemson v South Carolina State | L | 59-0 |
| NCAAF | 2014/09/06 16:30 | Clemson v South Carolina State | L | 73-7 |
| NCAAF | 2008/09/20 12:00 | Clemson v South Carolina State | L | 54-0 |
Home History
| NCAAF | 2021/09/04 23:00 | South Carolina State v Alabama | L | 41-42 |
| NCAAF | 2021/04/17 22:00 | South Carolina State v Delaware State | W | 31-28 |
| NCAAF | 2021/04/03 19:00 | South Carolina State v Alabama State | W | 14-7 |
| NCAAF | 2021/03/13 19:00 | Delaware State v South Carolina State | W | 9-17 |
| NCAAF | 2021/03/06 18:30 | Alabama v South Carolina State | L | 31-7 |
| NCAAF | 2019/11/23 18:00 | South Carolina State v Norfolk State | W | 20-17 |
| NCAAF | 2019/11/16 19:00 | South Carolina State v North Carolina Central | W | 24-0 |
| NCAAF | 2019/11/09 18:30 | Howard v South Carolina State | W | 21-62 |
Away History
| NCAAF | 2021/09/04 23:30 | Georgia v Clemson | L | 10-3 |
| NCAAF | 2021/01/02 01:00 | Ohio State v Clemson | L | 49-28 |
| NCAAF | 2020/12/19 21:00 | Clemson v Notre Dame | W | 34-10 |
| NCAAF | 2020/12/06 00:30 | Clemson v Virginia Tech | W | 45-10 |
| NCAAF | 2020/11/28 20:30 | Pittsburgh v Clemson | W | 17-52 |
| NCAAF | 2020/11/08 00:30 | Clemson v Notre Dame | L | 40-47 |
| NCAAF | 2020/10/31 16:00 | Boston College v Clemson | W | 28-34 |
| NCAAF | 2020/10/24 16:00 | Syracuse v Clemson | W | 21-47 |
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