Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Mark Elder
| NCAAF | 2018/09/22 20:00 | SE Missouri St v Eastern Kentucky | W | 14-23 |
| NCAAF | 2017/09/30 23:00 | SE Missouri St v Eastern Kentucky | L | 29-10 |
| NCAAF | 2019/11/02 17:00 | Austin Peay v Eastern Kentucky | L | 28-21 |
| NCAAF | 2019/10/26 19:00 | Eastern Kentucky v Eastern Illinois | W | 33-6 |
| NCAAF | 2019/10/19 19:00 | Eastern Kentucky v Murray State | W | 34-27 |
| NCAAF | 2019/10/05 19:00 | Tennessee Martin v Eastern Kentucky | L | 38-28 |
| NCAAF | 2019/09/28 22:00 | Tennessee State v Eastern Kentucky | W | 16-42 |
| NCAAF | 2019/09/21 17:00 | Eastern Kentucky v Presbyterian | W | 35-10 |
| NCAAF | 2019/09/14 17:00 | Eastern Kentucky v Indiana State | L | 7-19 |
| NCAAF | 2019/09/07 23:00 | Eastern Kentucky v Louisville | L | 0-42 |
| NCAAF | 2019/11/02 19:00 | SE Missouri St v Tennessee State | W | 32-13 |
| NCAAF | 2019/10/26 18:00 | Tennessee Martin v SE Missouri St | W | 10-17 |
| NCAAF | 2019/10/19 20:00 | SE Missouri St v Jacksonville State | W | 24-21 |
| NCAAF | 2019/10/12 19:00 | SE Missouri St v Austin Peay | L | 24-28 |
| NCAAF | 2019/10/05 23:00 | Tennessee Tech v SE Missouri St | W | 37-43 |
| NCAAF | 2019/09/21 18:00 | SE Missouri St v West Virginia State Yellow Jackets | W | 56-10 |
| NCAAF | 2019/09/14 23:30 | SE Missouri St v Missouri | L | 0-50 |
| NCAAF | 2019/09/08 00:00 | SE Missouri St v Montana State | L | 17-38 |