Stadium: Fisher Stadium Round: 1
Home Manager: John Garrett Away Manager: Bob Chesney
| NCAAF | 2018/10/27 17:05 | Holy Cross v Lehigh | W | 56-0 |
| NCAAF | 2018/10/12 23:00 | Harvard v Holy Cross | L | 33-31 |
| NCAAF | 2018/10/06 16:00 | New Hampshire v Holy Cross | L | 28-0 |
| NCAAF | 2018/09/29 17:05 | Bucknell v Holy Cross | L | 19-16 |
| NCAAF | 2018/09/22 17:05 | Holy Cross v Dartmouth | L | 14-34 |
| NCAAF | 2018/09/15 17:05 | Yale v Holy Cross | W | 28-31 |
| NCAAF | 2018/09/08 17:00 | Holy Cross v Boston College | L | 14-62 |
| NCAAF | 2018/09/01 17:00 | Holy Cross v Colgate | L | 17-24 |
| NCAAF | 2018/10/27 23:00 | Arkansas State v Lafayette | W | 43-47 |
| NCAAF | 2018/10/27 17:00 | Fordham v Lafayette | W | 13-21 |
| NCAAF | 2018/10/20 19:30 | Lafayette v Appalachian St | L | 17-27 |
| NCAAF | 2018/10/20 16:00 | Bucknell v Lafayette | W | 27-29 |
| NCAAF | 2018/10/13 21:00 | New Mexico State v Lafayette | W | 38-66 |
| NCAAF | 2018/10/13 19:30 | Georgetown v Lafayette | L | 13-6 |
| NCAAF | 2018/10/06 23:00 | Lafayette v Texas State | W | 42-27 |
| NCAAF | 2018/09/29 22:00 | Central Connecticut v Lafayette | W | 24-31 |