[49] Purdue 32-14 Northwestern [111] 2021-11-20 17:00
Stadium: Wrigley Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | L | 27-20 |
| NCAAF | 2019/11/09 17:00 | Purdue v Northwestern | W | 24-22 |
| NCAAF | 2018/08/31 00:00 | Northwestern v Purdue | L | 31-27 |
| NCAAF | 2017/11/12 00:00 | Purdue v Northwestern | L | 13-23 |
| NCAAF | 2016/11/12 17:00 | Northwestern v Purdue | L | 45-17 |
| NCAAF | 2015/11/14 17:00 | Northwestern v Purdue | L | 21-14 |
| NCAAF | 2014/11/22 17:00 | Purdue v Northwestern | L | 14-38 |
| NCAAF | 2010/10/09 12:00 | Northwestern v Purdue | W | 17-20 |
| NCAAF | 2008/10/18 12:00 | Northwestern v Purdue | L | 48-26 |
| NCAAF | 2007/10/27 12:00 | Purdue v Northwestern | W | 35-17 |
| NCAAF | 2006/10/14 12:00 | Northwestern v Purdue | W | 10-31 |
| NCAAF | 2005/10/15 12:00 | Purdue v Northwestern | L | 29-34 |
| NCAAF | 2004/10/30 12:00 | Northwestern v Purdue | L | 13-10 |
| NCAAF | 2003/11/01 12:00 | Purdue v Northwestern | W | 34-14 |
| NCAAF | 2002/10/26 12:00 | Northwestern v Purdue | W | 13-42 |
| NCAAF | 2001/10/27 12:00 | Purdue v Northwestern | W | 32-27 |
| NCAAF | 2000/10/14 12:00 | Northwestern v Purdue | W | 28-41 |
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