[49] Purdue 32-14 Northwestern [111] 2021-11-20 17:00
Stadium: Wrigley Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | L | 27-20 |
| NCAAF | 2019/11/09 17:00 | Purdue v Northwestern | W | 24-22 |
| NCAAF | 2018/08/31 00:00 | Northwestern v Purdue | L | 31-27 |
| NCAAF | 2017/11/12 00:00 | Purdue v Northwestern | L | 13-23 |
| NCAAF | 2016/11/12 17:00 | Northwestern v Purdue | L | 45-17 |
| NCAAF | 2015/11/14 17:00 | Northwestern v Purdue | L | 21-14 |
| NCAAF | 2014/11/22 17:00 | Purdue v Northwestern | L | 14-38 |
| NCAAF | 2010/10/09 12:00 | Northwestern v Purdue | W | 17-20 |
Home History
| NCAAF | 2021/11/13 20:30 | Purdue v Ohio State | L | 31-59 |
| NCAAF | 2021/11/06 19:30 | Michigan State v Purdue | W | 29-40 |
| NCAAF | 2021/10/30 19:30 | Purdue v Nebraska | W | 28-23 |
| NCAAF | 2021/10/23 19:00 | Wisconsin v Purdue | L | 30-13 |
| NCAAF | 2021/10/16 19:30 | Purdue v Iowa | W | 24-7 |
| NCAAF | 2021/10/02 16:00 | Minnesota v Purdue | L | 20-13 |
| NCAAF | 2021/09/25 19:30 | Illinois v Purdue | W | 9-13 |
| NCAAF | 2021/09/18 18:30 | Purdue v Notre Dame | L | 13-27 |
Away History
| NCAAF | 2021/11/13 17:00 | Northwestern v Wisconsin | L | 7-35 |
| NCAAF | 2021/11/06 23:00 | Iowa v Northwestern | L | 17-12 |
| NCAAF | 2021/10/30 19:30 | Minnesota v Northwestern | L | 41-14 |
| NCAAF | 2021/10/23 16:00 | Northwestern v Michigan | L | 7-33 |
| NCAAF | 2021/10/16 16:00 | Rutgers v Northwestern | W | 7-21 |
| NCAAF | 2021/10/02 23:30 | Northwestern v Nebraska | L | 7-56 |
| NCAAF | 2021/09/25 16:00 | Ohio v Northwestern | W | 6-35 |
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | L | 23-30 |
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