Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Myers Hendrickson
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | L | 31-30 |
| NCAAF | 2019/11/16 19:00 | SO Illinois v Western Illinois | L | 45-21 |
| NCAAF FCS | 2018/11/03 18:00 | Western Illinois v SO Illinois | W | 34-31 |
| NCAAF | 2017/11/18 19:00 | Western Illinois v SO Illinois | W | 28-14 |
| NCAAF | 2022/10/01 19:00 | Western Illinois v South Dakota State | L | 10-34 |
| NCAAF | 2022/09/24 20:00 | Northern Iowa v Western Illinois | L | 52-17 |
| NCAAF | 2022/09/17 20:00 | Southern Utah v Western Illinois | L | 17-10 |
| NCAAF | 2022/09/10 16:00 | Western Illinois v Minnesota | L | 10-62 |
| NCAAF | 2022/09/01 23:30 | Western Illinois v Tennessee Martin | L | 25-42 |
| NCAAF | 2021/11/20 19:00 | Western Illinois v Northern Iowa | L | 3-41 |
| NCAAF | 2021/11/06 17:00 | South Dakota v Western Illinois | L | 42-21 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | W | 31-38 |
| NCAAF | 2022/10/08 19:00 | SO Illinois v Missouri St | W | 38-21 |
| NCAAF | 2022/10/01 23:30 | SO Illinois v Illinois State | W | 19-14 |
| NCAAF | 2022/09/24 19:00 | North Dakota v SO Illinois | W | 17-34 |
| NCAAF | 2022/09/17 16:00 | SO Illinois v Northwestern | W | 31-24 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | L | 34-31 |
| NCAAF | 2022/09/03 23:00 | SO Illinois v Incarnate Word | L | 29-64 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | L | 7-38 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | W | 22-10 |