Stadium: Husky Stadium Round: 1
Home Manager: Vic Shealy Away Manager: Tim Rebowe
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | W | 44-14 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | W | 17-48 |
| NCAAF | 2019/11/09 21:00 | Houston Christian v Nicholls State | W | 27-48 |
| NCAAF FCS | 2018/11/03 19:00 | Nicholls State v Houston Christian | W | 41-20 |
| NCAAF | 2017/11/04 20:30 | Nicholls State v Houston Christian | W | 23-17 |
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | L | 33-36 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | L | 52-21 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | L | 16-42 |
| NCAAF | 2022/09/11 00:00 | Nicholls State v UL Monroe | L | 7-35 |
| NCAAF | 2022/09/03 21:00 | Nicholls State v South Alabama | L | 7-48 |
| NCAAF | 2021/11/19 00:00 | Nicholls State v SE Louisiana | W | 45-42 |
| NCAAF | 2021/11/13 21:00 | Incarnate Word v Nicholls State | L | 27-23 |
| NCAAF | 2021/11/06 17:00 | Nicholls State v McNeese State | W | 24-14 |
| NCAAF | 2022/10/01 20:00 | Houston Christian v Lamar | W | 37-34 |
| NCAAF | 2022/09/24 23:00 | Houston Christian v Texas State | L | 0-34 |
| NCAAF | 2022/09/10 23:00 | Lindenwood v Houston Christian | L | 21-20 |
| NCAAF | 2022/09/03 20:00 | Houston Christian v Northern Colorado | W | 46-34 |
| NCAAF | 2021/11/20 20:00 | Incarnate Word v Houston Christian | L | 55-14 |
| NCAAF | 2021/11/13 20:00 | McNeese State v Houston Christian | L | 44-3 |
| NCAAF | 2021/11/06 20:00 | Houston Christian v Northwestern State | L | 24-28 |
| NCAAF | 2021/10/30 20:00 | Houston Christian v Incarnate Word | L | 21-49 |