Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Adam Cushing
| NCAAF | 2021/02/28 20:00 | Eastern Illinois v SE Missouri St | L | 7-47 |
| NCAAF | 2019/11/16 18:00 | SE Missouri St v Eastern Illinois | L | 26-12 |
| NCAAF FCS | 2018/11/17 19:00 | Eastern Illinois v SE Missouri St | L | 32-38 |
| NCAAF | 2017/09/23 23:00 | Eastern Illinois v SE Missouri St | W | 19-16 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
| NCAAF | 2021/09/11 17:00 | Eastern Illinois v Dayton | L | 10-17 |
| NCAAF | 2021/09/04 23:00 | Eastern Illinois v South Carolina | L | 0-46 |
| NCAAF | 2021/08/28 22:00 | Eastern Illinois v Indiana State | L | 21-26 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Austin Peay | W | 30-14 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | L | 17-28 |
| NCAAF | 2021/09/25 19:00 | Tennessee State v SE Missouri St | W | 14-47 |
| NCAAF | 2021/09/18 16:00 | SE Missouri St v Missouri | L | 28-59 |
| NCAAF | 2021/09/11 23:00 | SE Missouri St v Sam Houston State | L | 14-52 |
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | L | 47-21 |