[66] South Carolina 28-31 Missouri [88] 2021-11-13 21:00
Stadium: Memorial Stadium/Faurot Field Round: 1
Home Manager: Eliah Drinkwitz Away Manager: Shane Beamer
Head to Head
| NCAAF | 2020/11/22 00:30 | Missouri v South Carolina | L | 17-10 |
| NCAAF | 2019/09/21 20:00 | South Carolina v Missouri | L | 14-34 |
| NCAAF | 2018/10/06 16:00 | Missouri v South Carolina | W | 35-37 |
| NCAAF | 2017/09/09 23:00 | South Carolina v Missouri | W | 31-13 |
| NCAAF | 2016/11/05 20:00 | Missouri v South Carolina | W | 21-31 |
| NCAAF | 2015/10/03 16:00 | Missouri v South Carolina | L | 24-10 |
| NCAAF | 2014/09/27 23:00 | South Carolina v Missouri | L | 20-21 |
| NCAAF | 2012/09/22 12:00 | South Carolina v Missouri | W | 31-10 |
Home History
| NCAAF | 2021/11/06 23:30 | Florida v South Carolina | W | 17-40 |
| NCAAF | 2021/10/23 23:30 | South Carolina v Texas A&M | L | 14-44 |
| NCAAF | 2021/10/16 20:00 | Vanderbilt v South Carolina | W | 20-21 |
| NCAAF | 2021/10/09 16:00 | South Carolina v Tennessee | L | 20-45 |
| NCAAF | 2021/10/02 19:30 | Troy v South Carolina | W | 14-23 |
| NCAAF | 2021/09/25 23:00 | Kentucky v South Carolina | L | 16-10 |
| NCAAF | 2021/09/18 23:00 | South Carolina v Georgia | L | 13-40 |
| NCAAF | 2021/09/11 16:00 | South Carolina v East Carolina | W | 20-17 |
Away History
| NCAAF | 2021/11/06 16:00 | Missouri v Georgia | L | 6-43 |
| NCAAF | 2021/10/30 19:00 | Missouri v Vanderbilt | W | 37-28 |
| NCAAF | 2021/10/16 16:00 | Texas A&M v Missouri | L | 35-14 |
| NCAAF | 2021/10/09 20:00 | North Texas v Missouri | W | 35-48 |
| NCAAF | 2021/10/02 16:00 | Tennessee v Missouri | L | 62-24 |
| NCAAF | 2021/09/25 16:00 | Missouri v Boston College | L | 34-41 |
| NCAAF | 2021/09/18 16:00 | SE Missouri St v Missouri | W | 28-59 |
| NCAAF | 2021/09/11 23:30 | Missouri v Kentucky | L | 28-35 |
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